主页 / 药理学 / Enzymes / Kinases / IκB Kinase / IκB Kinase Inhibitors / GSK 319347A

GSK 319347A

Cat. No. 5672 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective IKKε inhibitor
化学名： 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 319347A

GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

化合物库 for GSK 319347A

GSK 319347A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 319347A

分子量 469.53
公式 C22H19N3O5S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 862812-98-4
PubChem ID 11626927
InChI Key LDTAHRLHGHFHKP-UHFFFAOYSA-N
Smiles CS(C1=CC=CC=C1COC2=C(C#N)SC(N3C4=CC(OC)=C(OC)C=C4N=C3)=C2)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 319347A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.95 100

制备储备液 for GSK 319347A

以下数据基于产品分子量 469.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for GSK 319347A

参考文献是支持产品生物活性的出版物。

Bamborough et al (2006) 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase. Bioorg.Med.Chem.Lett. 16 6236 PMID: 16997559

If you know of a relevant reference for GSK 319347A, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 IκB Kinase Inhibitors

关键词: GSK 319347A, GSK 319347A supplier, GSK319347A, potent, selective, IKKepsilon, ε, inhibitor, inhibits, IkB, Kinase, NF-kB/IkB, 5672, Tocris Bioscience

1 篇 GSK 319347A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 319347A 的部分引用包括：

Mina J et al (2022) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Mol Oncol 16 130-147 PMID: 34058066

您是否知道使用了 Tocris GSK 319347A 的优秀论文？ 请告知我们.

GSK 319347A 的评论

目前没有该产品的评论。 Be the first to review GSK 319347A and earn rewards!

Have you used GSK 319347A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review