GSK 690693

Name: GSK 690693
Brand: Tocris Bioscience
SKU: 4144
Rating: 5 (1 reviews)

Cat. No. 4144 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Akt kinase inhibitor. Antitumor

化学名： 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

纯度： ≥98% (HPLC)

说明书

引用文献 (5)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GSK 690693

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC₅₀ < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

许可信息

Sold for research purposes only under agreement from GlaxoSmithKline

化合物库 for GSK 690693

GSK 690693 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 690693

分子量	425.48
公式	C₂₁H₂₇N₇O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	937174-76-0
PubChem ID	90488916
InChI Key	WONPMIMNXYCXKK-AWEZNQCLSA-N
Smiles	NC1=NON=C1C(N3CC)=NC2=C3C(CO[C@@H]4CNCCC4)=CN=C2C#CC(C)(C)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 690693

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	21.27	50

制备储备液 for GSK 690693

以下数据基于产品分子量 425.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.7 mL	23.5 mL	47.01 mL
2.5 mM	0.94 mL	4.7 mL	9.4 mL
5 mM	0.47 mL	2.35 mL	4.7 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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产品说明书 for GSK 690693

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GSK 690693

参考文献是支持产品生物活性的出版物。

Heerding et al (2008) Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 51 5663 PMID: 18800763

Rhodes et al (2008) Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 68 2366 PMID: 18381444

If you know of a relevant reference for GSK 690693, please let us know.

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关键词: GSK 690693, GSK 690693 supplier, GSK, 690693, inhibits, Akt, inhibitors, GSK690693, antitumor, antiproliferative, (Protein, Kinase, B), Protein, B/Akt, 4144, Tocris Bioscience

5 篇 GSK 690693 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 690693 的部分引用包括：

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Mol Neurosci 10 e0143319 PMID: 26619345

Nissa et al (2018) Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model. Neurobiol Dis 116 93-105 PMID: 29758256

Marisa et al (2013) α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome. Am J Pathol 183 1269-1280 PMID: 23911822

Sokołowska et al (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. Stem Cell Reports 52 48 PMID: 24243084

Khuituan et al (2012) Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D₃-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab 302 E903 PMID: 22275752

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Effects on Akt kinase activation in cancer.

By MARINA KOUTSIOUMPA on 10/18/2022

分析类型： In Vitro

种属： Human

GSK 690693 inhibitor was used in studies exploring the role of drug-induced activation of Akt kinase in pancreatic cancer cells. Results were consistent.

Pathways for GSK 690693

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.