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Herbimycin A

Cat. No. 1629 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Src family kinase inhibitor. Also Hsp90 inhibitor
化学名： (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
纯度： ≥95% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Herbimycin A

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

技术数据 for Herbimycin A

分子量 574.67
公式 C30H42N2O9
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 70563-58-5
PubChem ID 6436247
InChI Key MCAHMSDENAOJFZ-GDYSMBPZSA-N
Smiles O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Herbimycin A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1 2

制备储备液 for Herbimycin A

以下数据基于产品分子量 574.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.02 mM 87.01 mL 435.03 mL 870.06 mL
0.1 mM 17.4 mL 87.01 mL 174.01 mL
0.2 mM 8.7 mL 43.5 mL 87.01 mL
1 mM 1.74 mL 8.7 mL 17.4 mL

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产品说明书 for Herbimycin A

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Herbimycin A

参考文献是支持产品生物活性的出版物。

Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155 PMID: 8131836

McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987 PMID: 15051479

Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244 PMID: 16218955

If you know of a relevant reference for Herbimycin A, please let us know.

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关键词: Herbimycin A, Herbimycin A supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Antiangiogenics, Antibiotics, 1629, Tocris Bioscience

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Herbimycin A 的评论

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We studied mechanisms of resistance to Herbimycin A.
By Anonymous on 02/27/2019
种属： Human

We studied mechanisms of resistance to Herbimycin A (ansamycin antibiotics) in human breast cancer cell lines.

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