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HLI 373

Cat. No. 3503 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Hdm2 inhibitor; activates p53-dependent transcription
化学名： 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HLI 373

HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

化合物库 for HLI 373

HLI 373 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for HLI 373

分子量 414.33
公式 C18H23N5O2.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1782531-99-0
PubChem ID 72193867
InChI Key WUEMKAQTAIRDOA-UHFFFAOYSA-N
Smiles CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HLI 373

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 37.79 100
DMSO 3.78 10

制备储备液 for HLI 373

以下数据基于产品分子量 414.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.14 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for HLI 373

参考文献是支持产品生物活性的出版物。

Kitagaki et al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445 PMID: 18723490

Yang et al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24 PMID: 19037995

If you know of a relevant reference for HLI 373, please let us know.

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关键词: HLI 373, HLI 373 supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, Ubiquitin, E3, Ligases, 3503, Tocris Bioscience

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