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HTH 01-015

Cat. No. 5622 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective NUAK1 inhibitor
化学名： 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HTH 01-015

HTH 01-015 is a potent and selective NUAK1 inhibitor (IC50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro, to a similar extent as NUAK1 knockdown models.

许可信息

Sold under license from Dana-Farber Cancer Institute

化合物库 for HTH 01-015

HTH 01-015 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for HTH 01-015

分子量 468.55
公式 C26H28N8O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1613724-42-7
PubChem ID 78357766
InChI Key CHSDJDLAKKAWCI-UHFFFAOYSA-N
Smiles O=C1N(C)C2=C(N=C(NC3=CN(C4CCNCC4)N=C3)N=C2C)N(C)C5=CC6=CC=CC=C6C=C51

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HTH 01-015

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.85 100
ethanol 46.85 100

制备储备液 for HTH 01-015

以下数据基于产品分子量 468.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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参考文献 for HTH 01-015

参考文献是支持产品生物活性的出版物。

Banerjee et al (2014) Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 457 215 PMID: 24171924

If you know of a relevant reference for HTH 01-015, please let us know.

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关键词: HTH 01-015, HTH 01-015 supplier, HTH01-015, potent, selective, NUAK1, family, SNF1-like, kinase-1, inhibitors, inhibits, NUAK, 5622, Tocris Bioscience

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Pathways for HTH 01-015

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.
Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.