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Ibrutinib

Cat. No. 6813 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective BTK inhibitor
化学名： 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ibrutinib

Ibrutinib is a potent and selective BTK inhibitor (IC50= 0.5 nM). Selective for BTK against a screening panel of kinase enzymes. Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively). Also inhibits ErbB4 (IC50 = 0.25-3.4 nM). Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells. Reduces clinical arthritis scores in a mouse model.

化合物库 for Ibrutinib

Ibrutinib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ibrutinib

分子量 440.5
公式 C25H24N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 936563-96-1
PubChem ID 24821094
InChI Key XYFPWWZEPKGCCK-GOSISDBHSA-N
Smiles NC1=C2C(N([C@@H]3CCCN(C(C=C)=O)C3)N=C2C4=CC=C(C=C4)OC5=CC=CC=C5)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ibrutinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.05 100

制备储备液 for Ibrutinib

以下数据基于产品分子量 440.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Ibrutinib

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ibrutinib

参考文献是支持产品生物活性的出版物。

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.USA 107 13075 PMID: 20615965

Pan et al (2007) Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. Chem.Med.Chem. 2 58 PMID: 17154430

Estupiñán et al (2021) Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects. Front.Cell Dev.Biol. 9 630942 PMID: 33777941

If you know of a relevant reference for Ibrutinib, please let us know.

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关键词: Ibrutinib, Ibrutinib supplier, Potent, and, selective, Bruton, tyrosine, kinase, inhibitor, Btk, Brutons, Tyrosine, Kinase, (BTK), EGFR, 6813, Tocris Bioscience

1 篇 Ibrutinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ibrutinib 的部分引用包括：

John E et al (2021) Ibrutinib as a potential therapeutic for cocaine use disorder. Transl Psychiatry 11 623 PMID: 34880215

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