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Submit ReviewKaempferol
说明： Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
别名： Kempferol
化学名： 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for Kaempferol
Activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine. Kaempferol has antiviral activity against Japanese encephalitis virus (JEV) in infected BHK21 (EC50 = 21.5 μM). Kaempferol directly inhibits viral replication and protein expression by binding JEV frameshift site RNA (fsRNA). Kaempferol influences frameshift efficiency in virus-infected cells through interfering with a downstream RNA pseudoknot structure. Kaempferol has also been reported to exhibit activity against herpes simplex virus, influenza viruses (H1N1 and H9N2) and hepatitis B virus under in vitro conditions.
技术数据 for Kaempferol
| 分子量 | 286.24 |
| 公式 | C15H10O6 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 520-18-3 |
| PubChem ID | 5280863 |
| InChI Key | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
| Smiles | O=C2C1=C(O)C=C(O)C=C1OC(C3=CC=C(O)C=C3)=C2O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Kaempferol
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.62 | 100 | |
| ethanol | 28.62 | 100 |
制备储备液 for Kaempferol
以下数据基于产品分子量 286.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.49 mL | 17.47 mL | 34.94 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.49 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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产品说明书 for Kaempferol
参考文献 for Kaempferol
参考文献是支持产品生物活性的出版物。
Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19 PMID: 15324303
Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746 PMID: 19336918
Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17 PMID: 19356725
Vay et al (2009) Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation. J.Physiol. 580 39
Cho et al (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res. 67 8104 PMID: 17804722
Byun et al (2012) TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol. Bone 50 364 PMID: 22108137
Li et al (2008) In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L. Antiviral Res. 79 114 PMID: 18423640
If you know of a relevant reference for Kaempferol, please let us know.
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关键词: Kaempferol, Kaempferol supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer, TAZ, activates, transcriptional, coactivator, with, PDZ-binding, motif, osteogenesis, MSC, mesenchymal, stem, cells, antiviral, Kempferol, Inducers, IRE1, Calcium, Uniporter, RSK, Hippo/Yap, signaling, Stem, Cell, Signaling, Non-selective, Antivirals, 3603, Tocris Bioscience
2 篇 Kaempferol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Kaempferol 的部分引用包括：
Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796 PMID: 25279668
Lorena et al (2022) Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife 11 PMID: 35617485
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Kaempferol 的评论
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treat kaemferol in vitro system.
By
Anonymous on 11/03/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： mouse insulinoma cell lines
Islets were maintained in CMRL medium supplemented with 10% FBS and kaempferol
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Kaempferol
