Kenpaullone

Cat. No. 1398 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： GSK-3β inhibitor; also inhibits cdks

化学名： 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Kenpaullone

Kenpaullone is a GSK-3beta inhibitor (IC₅₀ = 0.23 μM). Also inhibits cyclin dependent kinases (cdks) in the sub micromolar range (reported IC₅₀ values are 0.4, 0.68-7 and 0.85 μM for cdk1, cdk2 and cdk5, respectively). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.

化合物库 for Kenpaullone

Kenpaullone is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Kenpaullone

分子量	327.18
公式	C₁₆H₁₁BrN₂O
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	142273-20-9
PubChem ID	3820
InChI Key	QQUXFYAWXPMDOE-UHFFFAOYSA-N
Smiles	BrC1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C34)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Kenpaullone

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	32.72	100

制备储备液 for Kenpaullone

以下数据基于产品分子量 327.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.28 mL	30.56 mL
5 mM	0.61 mL	3.06 mL	6.11 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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产品说明书 for Kenpaullone

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Kenpaullone

参考文献是支持产品生物活性的出版物。

Buolamwini (2000) Cell cycle targets in novel anticancer drug discovery. Curr.Pharm.Des. 6 379 PMID: 10788588

Schultz et al (1999) Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J.Med.Chem. 42 2909 PMID: 10425100

Zaharevitz et al (1999) Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 59 2566 PMID: 10363974

Lyssiotis et al (2009) Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc.Natl.Acad.Sci.U.S.A. 106 8912 PMID: 19447925

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for Kenpaullone, please let us know.

按标靶查看相关产品

关键词: Kenpaullone, Kenpaullone supplier, GSK-3β, GSK-3beta, inhibitors, inhibits, cdks, Potent, cyclin-dependent, kinase, GSK, Glycogen, Synthase, Kinase, 3, beta, Kinases, Cdk, Cyclin-Dependent, Protein, Carbohydrate, Metabolism, CDK1/cyclin, B, CDK2/cyclin, A, E, CDK5/cyclin/p35, stem, cells, Cyclin-dependent, Stem, Cell, Reprogramming, Non-selective, CDKs, 1398, Tocris Bioscience

2 篇 Kenpaullone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Kenpaullone 的部分引用包括：

Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6 6626 PMID: 25806427

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004

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Pathways for Kenpaullone

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