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Submit ReviewL-Azidonorleucine hydrochloride is an unnatural amino acid; methionine surrogate. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.
分子量 | 208.65 |
公式 | C6H12N4O2.HCl |
储存 | Store at -20°C |
CAS Number | 1454334-76-9 |
PubChem ID | 121235322 |
InChI Key | RCEAACZNVVRXSJ-JEDNCBNOSA-N |
Smiles | N[C@H](C(O)=O)CCCCN=[N+]=[N-].Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 20.86 | 100 |
以下数据基于产品分子量 208.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.79 mL | 23.96 mL | 47.93 mL |
5 mM | 0.96 mL | 4.79 mL | 9.59 mL |
10 mM | 0.48 mL | 2.4 mL | 4.79 mL |
50 mM | 0.1 mL | 0.48 mL | 0.96 mL |
参考文献是支持产品生物活性的出版物。
Alvarez-Castelao et al (2017) Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nat.Biotechnol. 35 1196 PMID: 29106408
Mahdavi et al (2016) Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis. J.Am.Chem.Soc. 138 4278 PMID: 26991063
If you know of a relevant reference for L-Azidonorleucine hydrochloride, please let us know.
关键词: L-Azidonorleucine hydrochloride, L-Azidonorleucine hydrochloride supplier, unnatural, amino, acid, UAA, ANL, methionine, surrogate, BONCAT, FUNCAT, bio-orthogonal, fluorescent, non-canonical, tagging, methionyl, tRNA, synthetase, metRS, Biochemicals, and, Molecular, Biology, Unnatural, Amino, Acids, 6585, Tocris Bioscience
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