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LaKe

Cat. No. 8888 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells
化学名： (3R)-3-Hydroxybutyl (2S)-2-hydroxypropanoate and (1R)-3-Hydroxy-1-methylpropyl (2S)-2-hydroxypropanoate
纯度： ≥95%
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LaKe

LaKe is a metabolite that undergoes hydrolytic conversion to yield (S)-lactate (Lac) and (R)-1,3-butanediol (BHB) in cells, two metabolites naturally released during strenuous exercise and prolonged fasting. In vivo, oral ingestion of LaKe in rats, results in an increase of Lac and BHB plasma levels, triggering reduced lipolysis and elevation of the appetite-suppressing compound Lac-Phe (Cat. No. 7942).

许可信息

Sold under license from Mmimetika Biosciences

技术数据 for LaKe

分子量 162.19
公式 C7H14O4
储存 Store at -20°C
纯度 ≥95%
InChI Key YYIHZASOYSUEJO-NTPRZCPUSA-N
Smiles C[C@@H](C(O[C@@H](CCO)C)=O)O.C[C@@H](C(OCC[C@@H](C)O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LaKe

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.22 100

制备储备液 for LaKe

以下数据基于产品分子量 162.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 6.17 mL 30.83 mL 61.66 mL
5 mM 1.23 mL 6.17 mL 12.33 mL
10 mM 0.62 mL 3.08 mL 6.17 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

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Dilution Calculator

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参考文献 for LaKe

参考文献是支持产品生物活性的出版物。

Ottosen et al (2024) Preparation and preclinical characterization of a simple ester for dual exogenous supply of lactate and beta-hydroxybutyrate. J.Agric.Food Chem. 72 19883 PMID: 39214666

If you know of a relevant reference for LaKe, please let us know.

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关键词: LaKe, LaKe supplier, lactate, ketones, N-L-lactoyl-phenylalanine, Lac-Phe, appetite, regulation, orally, bioavailable, in, vivo, exercise, Biochemicals, and, Molecular, Biology, 8888, Tocris Bioscience

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