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Lenalidomide

Cat. No. 6305 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
化学名： 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lenalidomide

Lenalidomide is a thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

化合物库 for Lenalidomide

Lenalidomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Lenalidomide

分子量 259.26
公式 C13H13N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 191732-72-6
PubChem ID 216326
InChI Key GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smiles NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lenalidomide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.93 100

制备储备液 for Lenalidomide

以下数据基于产品分子量 259.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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产品说明书 for Lenalidomide

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Lenalidomide

参考文献是支持产品生物活性的出版物。

Petzold et al (2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 532 127 PMID: 26909574

Krönke et al (2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523 183 PMID: 26131937

Donovan et al (2018) Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223

Chamberlain et al (2019) Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 10 1592 PMID: 31857833

If you know of a relevant reference for Lenalidomide, please let us know.

按标靶查看相关产品

关键词: Lenalidomide, Lenalidomide supplier, tumor, necrosis, factor, 1α, alpha, alfa, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, CELMoD, E3, ligase, modulators, SALL4, casein, kinase, CK1, degrades, immunomodulators, immunomodulatory, imide, IMiDs, molecular, glue, modulating, CELMoDs, Ubiquitin, Ligases, Cytokines, Antiangiogenics, Other, Transcription, Factors, Molecular, Glues, 6305, Tocris Bioscience

1 篇 Lenalidomide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lenalidomide 的部分引用包括：

Fang et al (2020) Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism. Oncotarget 11 4224-4242 PMID: 33245718

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Lenalidomide 的评论

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Lenalidomide as Ikaros inhibitor.
By Binod G C on 05/06/2021
种属： Human
细胞系/组织： Ba/F

Lenalidomide was used to inhibit Ikaros to examine target gene expression. 2um concentration was used.

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