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Submit ReviewLP 922761
说明： Potent AAK1 inhibitor; peripherally restricted
化学名： tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate
纯度： ≥98% (HPLC)
生物活性 for LP 922761
LP 922761 is a potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.
化合物库 for LP 922761
LP 922761 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for LP 922761
| 分子量 | 410.47 |
| 公式 | C21H26N6O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1454808-95-7 |
| PubChem ID | 86696405 |
| InChI Key | YNQNYIHMAZLJAV-UHFFFAOYSA-N |
| Smiles | CN(C(OC(C)(C)C)=O)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C(N)=O)C=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LP 922761
参考文献 for LP 922761
参考文献是支持产品生物活性的出版物。
Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID: 27411717
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关键词: LP 922761, LP 922761 supplier, LP922761, AAK1, adapter, protein-2, AP2, associated, kinase, 1, potent, inhibitors, inhibits, peripherally, restricted, orally, bioavailable, Other, Kinases, 6229, Tocris Bioscience
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