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说明： Negative control of LY 294002 (Cat. No. 1130)
化学名： 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
纯度： ≥99% (HPLC)
生物活性 for LY 303511
LY 303511 is a negative control compound for LY 294002 PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.
Active Analog also available.
技术数据 for LY 303511
| 分子量 | 306.36 |
| 公式 | C19H18N2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 154447-38-8 |
| PubChem ID | 3971 |
| InChI Key | NGAGMBNBKCDCDJ-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for LY 303511
参考文献 for LY 303511
参考文献是支持产品生物活性的出版物。
El-kholy et al (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism. FASEB J. 17 720 PMID: 12586735
Choi et al (2004) LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 559 141 PMID: 14960322
Kristof et al (2005) LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 314 1134 PMID: 15923340
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关键词: LY 303511, LY 303511 supplier, Negative, control, LY, 294002, LY294002, PI3K, Phosphoinositide, PI, 3-Kinases, PIP2, Inositol, Lipids, LY303511, BETbromodomains, inhibitors, inhibits, BRD2, BRD3, BRD4, 3-Kinase, Bromodomains, 2418, Tocris Bioscience
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