Metformin hydrochloride

Name: Metformin hydrochloride
Brand: Tocris Bioscience
SKU: 2864
Rating: 4 (2 reviews)

Cat. No. 2864 17 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Activator of LKB1/AMPK; antidiabetic agent

化学名： N,N-Dimethylimidodicarbonimidic diamide hydrochloride

说明书

引用文献 (17)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Metformin hydrochloride

Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Metformin hydrochloride prevents brain atrophy, and slows the pace of aging across diverse tissues in animal studies.

化合物库 for Metformin hydrochloride

Metformin hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Metformin hydrochloride

分子量	165.62
公式	C₄H₁₁N₅.HCl
储存	Store at RT
CAS Number	1115-70-4
PubChem ID	14219
InChI Key	OETHQSJEHLVLGH-UHFFFAOYSA-N
Smiles	NC(NC(N(C)C)=N)=N.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Metformin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	16.56	100
	DMSO	3.31	20 温和加热

制备储备液 for Metformin hydrochloride

以下数据基于产品分子量 165.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	6.04 mL	30.19 mL	60.38 mL
5 mM	1.21 mL	6.04 mL	12.08 mL
10 mM	0.6 mL	3.02 mL	6.04 mL
50 mM	0.12 mL	0.6 mL	1.21 mL

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产品说明书 for Metformin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Metformin hydrochloride

参考文献是支持产品生物活性的出版物。

Shaw et al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of MetF.. Science 310 1642 PMID: 16308421

Towler and Hardie (2007) AMP-activated protein kinase in metabolic control and Ins signalling. Circ.Res. 100 328 PMID: 17307971

Hirsch et al (2013) MetF. inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc.Natl.Acad.Sci.USA 110 972 PMID: 23277563

Wang et al (2012) MetF. activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 11 23 PMID: 22770240

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

Wheaton et al (2014) MetfF inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife 3 e02242 PMID: 24843020

Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859

Yang et al (2024) Metformin decelerates aging clock in male monkeys. Cell 187 1 PMID: 39270656

If you know of a relevant reference for Metformin hydrochloride, please let us know.

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关键词: Metformin hydrochloride, Metformin hydrochloride supplier, activators, LKB1/AMPK, antidiabetic, agent, AMP-Activated, Protein, Kinases, Enzyme, Substrates, mitochondrial, complex, I, MRC1, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, /, Activators, AMPK, Neural, Stem, Cells, Autophagy, Oxidative, Phosphorylation, Coronavirus, 2864, Tocris Bioscience

17 篇 Metformin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Metformin hydrochloride 的部分引用包括：

Bowling et al (2019) Altered steady state and activity-dependent de novo protein expression in fragile X syndrome. Nat Commun 10 1710 PMID: 30979884

Li et al (2016) Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell 7 478 PMID: 27271327

Edris et al (2012) Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. Sarcoma 2012 805614 PMID: 22919280

Valente et al (2014) OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med 70 117 PMID: 24561578

Lin et al (2015) Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats. Nat Commun 9 4709 PMID: 26316709

Naka et al (2015) Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. BMC Cancer 6 8039 PMID: 26289811

Abdou et al (2014) A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol 34 4257 PMID: 25225331

Yang et al (2024) Metformin decelerates aging clock in male monkeys. Cell 187 1 PMID: 39270656

Marinangeli et al (2018) AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation. iScience 9 1 PMID: 30368077

Xintaropoulou et al (2018) Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment. BMC Cancer 18 636 PMID: 29866066

Soliman et al (2017) Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line. Metabolomics (Los Angel) 6 PMID: 28217402

Yan et al (2015) Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat 1 5 PMID: 26120598

Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500 PMID: 25751140

Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. PLoS One 13 327 PMID: 23819460

Westergard et al (2019) Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med 11 PMID: 30617154

Massey (2017) Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage. Sci Rep 7 40778 PMID: 28106079

Xintaropoulou et al (2015) A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget 6 25677 PMID: 26259240

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Metformin treatment.

By Anonymous on 03/21/2020

分析类型： In Vitro

种属： Human

细胞系/组织： HPAF

1 mM add to media for 24 hours

PMID: 28217402

AMPK activation.

By Anonymous on 01/30/2018

分析类型： Ex Vivo

种属： Mouse

细胞系/组织： Brain slice

Used in brain slices to activate AMPK, but no effect on cell dynamic was found. No positive control was used though, so unsure if lack of effect is due to drug...

Pathways for Metformin hydrochloride

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.