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MI 14

Cat. No. 5604 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PI 4-kinase IIIβ inhibitor
化学名： N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MI 14

MI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.

化合物库 for MI 14

MI 14 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for MI 14

分子量 450.94
公式 C19H23ClN6O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1715934-43-2
PubChem ID 91758319
InChI Key PSTAJIONBVMKLA-UHFFFAOYSA-N
Smiles CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MI 14

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.02 20

制备储备液 for MI 14

以下数据基于产品分子量 450.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.09 mL 55.44 mL 110.88 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
2 mM 1.11 mL 5.54 mL 11.09 mL
10 mM 0.22 mL 1.11 mL 2.22 mL

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参考文献 for MI 14

参考文献是支持产品生物活性的出版物。

Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID: 25897704

If you know of a relevant reference for MI 14, please let us know.

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关键词: MI 14, MI 14 supplier, MI14, antivirals, phostphatidylinositol, 4, kinases, inhibitors, inhibits, IIIbeta, PI4-Kinase, RNA, viruses, potent, selective, Other, Kinases, Non-selective, Antivirals, 5604, Tocris Bioscience

1 篇 MI 14 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MI 14 的部分引用包括：

Wooree et al (2021) Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist. Elife 10 PMID: 34013886

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