ML 120B dihydrochloride

Name: ML 120B dihydrochloride
Brand: Tocris Bioscience
SKU: 4899
Rating: 5 (1 reviews)

Cat. No. 4899 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Novel IKK2-selective inhibitor

化学名： N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 120B dihydrochloride

ML 120B dihydrochloride is a novel, ATP-competitive IKK2-selective inhibitor (IC₅₀ = 60 nM at 50 μM ATP). Exhibits no inhibition at IKK1 (EC₅₀ >100 μM), IKKε (EC₅₀ >100 μM) or a panel of 28 other kinases (EC₅₀ >50 μM). Exhibits antitumor activity in lymphoma-bearing SCID mice. Demonstrates synergistic cytotoxic effects with vincristine (Cat. No. 1257).

化合物库 for ML 120B dihydrochloride

ML 120B dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 120B dihydrochloride

分子量	439.72
公式	C₁₉H₁₅ClN₄O₂.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1782573-78-7
PubChem ID	90488985
InChI Key	AWKOVWFBTRXQLW-UHFFFAOYSA-N
Smiles	ClC1=C(OC)C(NC(C4=CC=CN=C4C)=O)=C2C(C(C=CN=C3)=C3N2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 120B dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	8.79	20
	water	2.2	5 温和加热

制备储备液 for ML 120B dihydrochloride

以下数据基于产品分子量 439.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	11.37 mL	56.85 mL	113.71 mL
1 mM	2.27 mL	11.37 mL	22.74 mL
2 mM	1.14 mL	5.69 mL	11.37 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for ML 120B dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 120B dihydrochloride

参考文献是支持产品生物活性的出版物。

Catley et al (2006) Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol.Pharmacol. 70 697 PMID: 16687566

Nagashima et al (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood 107 4266 PMID: 16439676

Al-Katib et al (2010) I-kappa-kinase-2 (IKK-2) inhibition potentiates vincri. cytotoxicity in non-Hodgkin's lymphoma. Mol.Cancer 9 1476 PMID: 20809973

If you know of a relevant reference for ML 120B dihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 IκB Kinase Inhibitors

关键词: ML 120B dihydrochloride, ML 120B dihydrochloride supplier, ML120B, dihydrochloride, IKK2, inhibitor, ikk-2, NF-kappaB, NF-kB, NF-κ, IκB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, αb, kinases, NF-kB/IkB, IkB, Kinase, 4899, Tocris Bioscience

篇 ML 120B dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 ML 120B dihydrochloride 的引用文献。您是否知道使用了 Tocris ML 120B dihydrochloride 的优秀论文？请告知我们.