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ML 281

Cat. No. 4880 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： STK33 inhibitor
化学名： N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 281

ML 281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.

化合物库 for ML 281

ML 281 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 281

分子量 389.47
公式 C22H19N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1404437-62-2
PubChem ID 53377448
InChI Key HWOYIOLMBQSTQS-UHFFFAOYSA-N
Smiles CC(C)C1=CC(C2=NC(C=CC=C3)=C3NC2=O)=C(NC(C4=CC=CS4)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 281

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.95 100

制备储备液 for ML 281

以下数据基于产品分子量 389.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.84 mL 25.68 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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参考文献 for ML 281

参考文献是支持产品生物活性的出版物。

Weiwer et al (2012) A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 3 1034 PMID: 23256033

If you know of a relevant reference for ML 281, please let us know.

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关键词: ML 281, ML 281 supplier, ML281, STK33, kinases, inhibitors, inhibits, selective, Other, Kinases, 4880, Tocris Bioscience

1 篇 ML 281 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 281 的部分引用包括：

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

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