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NIBR LTSi

Cat. No. 8175 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective LATS inhibitor; activates YAP signaling
化学名： N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NIBR LTSi

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC50 = 1.4 nM). Also activates YAP signaling (EC50 = 1.0 - 2.7 μM). Promotes liver organoid formation (EC50 = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

技术数据 for NIBR LTSi

分子量 308.39
公式 C18H20N4O
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 171115368
InChI Key IYFCFYWXRIVCTH-OAHLLOKOSA-N
Smiles C1(NC2=CC=C(O[C@H]3CNCCC3)C=C2)=CC=NC4=C1C=CN4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NIBR LTSi

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.84 100

制备储备液 for NIBR LTSi

以下数据基于产品分子量 308.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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参考文献 for NIBR LTSi

参考文献是支持产品生物活性的出版物。

Namoto et al (2024) NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell 31 554 PMID: 38579685

If you know of a relevant reference for NIBR LTSi, please let us know.

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关键词: NIBR LTSi, NIBR LTSi supplier, NIBRLTSi, large, tumor, suppressor, kinase, LATS, LATS1, YAP, signaling, liver, organoid, hepatocyte, ISC, stem, cells, proliferation, bioavailable, Other, Kinases, Hippo/Yap, 8175, Tocris Bioscience

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