NSC 33994

Discontinued Product

4338 has been discontinued.

View all JAK products.
说明: JAK2 inhibitor
化学名: E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)

生物活性 for NSC 33994

NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.

技术数据 for NSC 33994

分子量 438.65
公式 C28H42N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 82058-16-0
PubChem ID 5473838
InChI Key QFNJFVBKASKGEU-OCEACIFDSA-N
Smiles CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NSC 33994

参考文献是支持产品生物活性的出版物。

Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617

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关键词: NSC 33994, NSC 33994 supplier, NSC33994, jak2, janus, tyrosine, kinase, inhibitors, inhibits, JAK, Kinase, 4338, Tocris Bioscience

1 篇 NSC 33994 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 33994 的部分引用包括:

Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105


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Pathways for NSC 33994

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.