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Submit ReviewNSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
分子量 | 438.65 |
公式 | C28H42N2O2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 82058-16-0 |
PubChem ID | 5473838 |
InChI Key | QFNJFVBKASKGEU-OCEACIFDSA-N |
Smiles | CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617
关键词: NSC 33994, NSC 33994 supplier, NSC33994, jak2, janus, tyrosine, kinase, inhibitors, inhibits, JAK, Kinase, 4338, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 NSC 33994 的部分引用包括:
Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105
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