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NVP 231

Cat. No. 3960 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective and reversible CerK inhibitor
化学名： N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NVP 231

NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.

化合物库 for NVP 231

NVP 231 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NVP 231

分子量 431.55
公式 C25H25N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 362003-83-6
PubChem ID 4096211
InChI Key MVSSJPGNLQPWSW-UHFFFAOYSA-N
Smiles O=C(C3=CC=CC=C3)NC2=NC(C=C1)=C(S2)C=C1NC(C45CC(C6)CC(CC6C5)C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NVP 231

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.16 100
ethanol 2.16 5

制备储备液 for NVP 231

以下数据基于产品分子量 431.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for NVP 231

参考文献是支持产品生物活性的出版物。

Graf et al (2009) A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 384 166 PMID: 18831956

Niwa et al (2009) Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 77 389 PMID: 19323974

Graf et al (2009) Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 74 925 PMID: 18612076

If you know of a relevant reference for NVP 231, please let us know.

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关键词: NVP 231, NVP 231 supplier, NVP231, potent, reversible, selective, ceramide, kinase, CerK, inhibitors, inhibits, Other, Kinases, 3960, Tocris Bioscience

1 篇 NVP 231 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NVP 231 的部分引用包括：

Mikhail et al (2021) Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate. EMBO J 40 e106272 PMID: 33942347

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