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Obatoclax mesylate

Cat. No. 6539 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of Bcl-2 family members; antiapoptotic
别名： GX15-070
化学名： 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Obatoclax mesylate

Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC50 values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.

化合物库 for Obatoclax mesylate

Obatoclax mesylate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Obatoclax mesylate

分子量 413.49
公式 C20H19N3O.CH3SO3H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 803712-79-0
PubChem ID 16681698
InChI Key ZVAGBRFUYHSUHA-LZOXOEDVSA-N
Smiles CS(O)(=O)=O.COC1=CC(C2=CC3=CC=CC=C3N2)=N/C1=C/C4=C(C=C(N4)C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Obatoclax mesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.67 50

制备储备液 for Obatoclax mesylate

以下数据基于产品分子量 413.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.84 mL 24.18 mL 48.37 mL
2.5 mM 0.97 mL 4.84 mL 9.67 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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产品说明书 for Obatoclax mesylate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Obatoclax mesylate

参考文献是支持产品生物活性的出版物。

Nguyen et al (2007) Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc.Natl.Acad.Sci.U.S.A. 104 19512 PMID: 18040043

Zhai et al (2006) Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 13 1419 PMID: 16645636

If you know of a relevant reference for Obatoclax mesylate, please let us know.

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关键词: Obatoclax mesylate, Obatoclax mesylate supplier, Obatoclax, GX15-070, Bcl-2, family, inhibitors, inhibits, antiapoptotic, Family, 6539, Tocris Bioscience

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