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Omipalisib

Cat. No. 6792 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
别名： GSK2126458
化学名： 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Omipalisib

Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.

化合物库 for Omipalisib

Omipalisib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Omipalisib

分子量 505.5
公式 C25H17F2N5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1086062-66-9
PubChem ID 25167777
InChI Key CGBJSGAELGCMKE-UHFFFAOYSA-N
Smiles COC1=NC=C(C2=CC3=C(N=CC=C3C4=CN=NC=C4)C=C2)C=C1NS(=O)(C5=C(C=C(C=C5)F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Omipalisib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.11 20

制备储备液 for Omipalisib

以下数据基于产品分子量 505.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.89 mL 49.46 mL 98.91 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
2 mM 0.99 mL 4.95 mL 9.89 mL
10 mM 0.2 mL 0.99 mL 1.98 mL

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参考文献 for Omipalisib

参考文献是支持产品生物活性的出版物。

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39 PMID: 24900173

If you know of a relevant reference for Omipalisib, please let us know.

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关键词: Omipalisib, Omipalisib supplier, PI, 3-Kinase, PI3K, mTOR, DNA-PK, highly, potent, inhibitors, inhibits, orally, bioavailable, anticancer, GSK2126458, DNA-dependent, Protein, Kinase, 6792, Tocris Bioscience

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