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OSU 03012

Cat. No. 5682 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PDPK1 (PDK1) inhibitor; inhibits Akt signaling
化学名： 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for OSU 03012

OSU 03012 is a PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro. Attenuates tumor growth of medulloblastoma xenografts in mice.

化合物库 for OSU 03012

OSU 03012 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for OSU 03012

分子量 460.45
公式 C26H19F3N4O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 742112-33-0
PubChem ID 10027278
InChI Key YULUCECVQOCQFQ-UHFFFAOYSA-N
Smiles O=C(CN)NC(C=C1)=CC=C1N2C(C(C=C3)=CC4=C3C5=CC=CC=C5C=C4)=CC(C(F)(F)F)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for OSU 03012

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.05 100

制备储备液 for OSU 03012

以下数据基于产品分子量 460.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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参考文献 for OSU 03012

参考文献是支持产品生物活性的出版物。

Baryawno et al (2010) Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/β-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res. 70 266 PMID: 20028853

Yacoub et al (2006) OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Mol.Pharmacol. 70 589 PMID: 16622074

Zhu et al (2004) From the cyclooxygenase-2 inhibitor cele. to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 64 4309 PMID: 15205346

If you know of a relevant reference for OSU 03012, please let us know.

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关键词: OSU 03012, OSU 03012 supplier, OSU03012, PDK1, Akt, antitumor, anticancer, 3-phospho-inositide-dependent, kinases-1, PDPK1, Phosphoinositide-dependent, Kinase, 1, (Protein, B), Protein, B/Akt, 5682, Tocris Bioscience

1 篇 OSU 03012 的引用文献

引用文献是使用了 Tocris 产品的出版物。 OSU 03012 的部分引用包括：

Hye Jung et al (2022) P2Y2R-Mediated PAK1 Activation Is Involved in ESM-1 Overexpression in RT-R-MDA-MB-231 through FoxO1 Regulation. Cancers (Basel) 14 PMID: 36077661

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