主页 / 药理学 / Enzymes / Kinases / MEK / MEK Inhibitors / PD 334581

PD 334581

Cat. No. 4824 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MEK1 inhibitor
化学名： N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PD 334581

PD 334581 is an inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).

化合物库 for PD 334581

PD 334581 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 334581

分子量 545.3
公式 C20H19F3IN5O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 548756-68-9
PubChem ID 5287529
InChI Key LZZYEMSEMRUPIM-UHFFFAOYSA-N
Smiles FC1=CC(I)=CC=C1NC2=C(F)C(F)=CC=C2C3=NN=C(NCCN4CCOCC4)O3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 334581

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.53 100
ethanol 5.45 10

制备储备液 for PD 334581

以下数据基于产品分子量 545.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.17 mL 18.34 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for PD 334581

参考文献是支持产品生物活性的出版物。

Zhang et al (2009) Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 9 28 PMID: 19104514

Ohren et al (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 11 1192 PMID: 15543157

If you know of a relevant reference for PD 334581, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 MEK Inhibitors

关键词: PD 334581, PD 334581 supplier, PD334581, MEK1, kinase, inhibitors, inhibits, mitogen, activated, protein, 1, MEK, 4824, Tocris Bioscience

篇 PD 334581 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 PD 334581 的引用文献。 您是否知道使用了 Tocris PD 334581 的优秀论文？ 请告知我们.

PD 334581 的评论

目前没有该产品的评论。 Be the first to review PD 334581 and earn rewards!

Have you used PD 334581?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for PD 334581

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.