PF 431396

Cat. No. 4278 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Dual FAK/PYK2 inhibitor

化学名： N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide

纯度： ≥98% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 431396

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC₅₀ values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 431396

PF 431396 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 431396

分子量	506.5
公式	C₂₂H₂₁F₃N₆O₃S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	717906-29-1
PubChem ID	11598628
InChI Key	POJZIZBONPAWIV-UHFFFAOYSA-N
Smiles	O=C2NC1=CC=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC=C4N(C)S(=O)(C)=O)=N3)C=C1C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 431396

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.32	50

制备储备液 for PF 431396

以下数据基于产品分子量 506.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.95 mL	19.74 mL	39.49 mL
2.5 mM	0.79 mL	3.95 mL	7.9 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

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产品说明书 for PF 431396

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 431396

参考文献是支持产品生物活性的出版物。

Buckbinder et al (2007) Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc.Natl.Acad.Sci.USA 104 10619 PMID: 17537919

Han et al (2009) Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem. 284 13193 PMID: 19244237

Allen et al (2010) Emerging targets in osteoporosis disease modification. J.Med.Chem. 53 4332 PMID: 20218623

If you know of a relevant reference for PF 431396, please let us know.

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