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Submit ReviewPI 828
说明： PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
化学名： 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for PI 828
PI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.
技术数据 for PI 828
| 分子量 | 322.36 |
| 公式 | C19H18N2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 942289-87-4 |
| PubChem ID | 25181195 |
| InChI Key | WUKMIBOGGXMBAC-UHFFFAOYSA-N |
| Smiles | O=C2C=C(N3CCOCC3)OC1=C(C4=CC=C(N)C=C4)C=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PI 828
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.24 | 100 |
制备储备液 for PI 828
以下数据基于产品分子量 322.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.51 mL | 31.02 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for PI 828
参考文献 for PI 828
参考文献是支持产品生物活性的出版物。
Gharbi et al (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J. 404 15 PMID: 17302559
If you know of a relevant reference for PI 828, please let us know.
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关键词: PI 828, PI 828 supplier, PI, 3-kinase, inhibitors, inhibits, potent, LY, 294002, PI3K, Phosphoinositide, 3-Kinases, PI828, 3-Kinase, Inositol, Lipids, 2814, Tocris Bioscience
5 篇 PI 828 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PI 828 的部分引用包括：
Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699
Moser et al (2014) Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 20 4274 PMID: 25125259
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Neurosci 10 e0143319 PMID: 26619345
Li et al (2011) TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect 119 784 PMID: 21245013
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887
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PI 828 的评论
平均评分: 5 (Based on 1 Review.)
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Treat PI828 for HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized.
By
Wen Ding on 10/01/2019
分析类型： In Vitro
种属： Human
细胞系/组织： 293
The HEK293 (293) cell line stably co-transfected with rat nAChR subunits alpha 4 and beta 2 are well characterized, and they were maintained as described previously. This cell line also expresses TNFR1 (only weak expression of TNFR2 is detected) and no additional human nAChR subunits or acetylcholine synthetic enzymes are detected. As before PI 828 (20 nM) treatments were conducted 48 hours after cell plating
