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Submit Review(R)-Norketamine hydrochloride
说明： NMDA receptor modulator; analgesic
化学名： (R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for (R)-Norketamine hydrochloride
(R)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.
S-enantiomer and racemate also available.
技术数据 for (R)-Norketamine hydrochloride
| 分子量 | 260.16 |
| 公式 | C12H14ClNO.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 83777-68-8 |
| PubChem ID | 71743680 |
| InChI Key | CLPOJGPBUGCUKT-UTONKHPSSA-N |
| Smiles | ClC1=C([C@@]2(N)C(CCCC2)=O)C=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (R)-Norketamine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 5.2 | 20 | |
| DMSO | 26.02 | 100 |
制备储备液 for (R)-Norketamine hydrochloride
以下数据基于产品分子量 260.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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产品说明书 for (R)-Norketamine hydrochloride
参考文献 for (R)-Norketamine hydrochloride
参考文献是支持产品生物活性的出版物。
Singh et al (2016) KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 11 e0149499 PMID: 27096720
Holtman et al (2008) Effects of norKA enantiomers in rodent models of persistent pain. Pharmacol.Biochem.Behav. 909 676 PMID: 18586315
If you know of a relevant reference for (R)-Norketamine hydrochloride, please let us know.
关键词: (R)-Norketamine hydrochloride, (R)-Norketamine hydrochloride supplier, NMDA, modulators, modulates, analgesic, ketamine, metabolites, Receptors, Ketamine, and, Metabolites, 5996, Tocris Bioscience
1 篇 (R)-Norketamine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (R)-Norketamine hydrochloride 的部分引用包括：
Ago et al (2019) (R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism. Int J Neuropsychopharmacol 22 665 PMID: 31325908
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