主页 / 药理学 / Enzymes / Kinases / Other Kinases / Other Kinase Inhibitors / SGC AAK1 1

SGC AAK1 1

Cat. No. 6528 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： AAK1 and BMP2K inhibitor; activates Wnt signaling
化学名： N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SGC AAK1 1

SGC AAK1 1 is an adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-AAK1-1 probe summary on the SGC website.

化合物库 for SGC AAK1 1

SGC AAK1 1 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SGC AAK1 1

分子量 427.52
公式 C21H25N5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2247894-32-0
PubChem ID 134812845
InChI Key UCBIQZUJJSVQHL-UHFFFAOYSA-N
Smiles O=C(NC1=NNC2=C1C=CC(C3=CC=CC(NS(=O)(N(CC)CC)=O)=C3)=C2)C4CC4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SGC AAK1 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.75 100

制备储备液 for SGC AAK1 1

以下数据基于产品分子量 427.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.7 mL 23.39 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for SGC AAK1 1

参考文献是支持产品生物活性的出版物。

Agajanian et al (2019) WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 26 79 PMID: 30605688

If you know of a relevant reference for SGC AAK1 1, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Kinase Inhibitors

关键词: SGC AAK1 1, SGC AAK1 1 supplier, SGCAAK11, AAK1, BMP2K, inhibitors, inhibits, WNT, signaling, activators, activates, BMP-2-inducible, protein, kinase, Adaptor-associated, 1, Other, Kinases, Wnt, Signaling, 6528, Tocris Bioscience

篇 SGC AAK1 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 SGC AAK1 1 的引用文献。 您是否知道使用了 Tocris SGC AAK1 1 的优秀论文？ 请告知我们.

SGC AAK1 1 的评论

目前没有该产品的评论。 Be the first to review SGC AAK1 1 and earn rewards!

Have you used SGC AAK1 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review