SGC CK2-1

Cat. No. 7450 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent CK2A2 and CK2A1 inhibitor; also inhibits DYRK2

化学名： N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SGC CK2-1

SGC CK2-1 is a potent inhibitor of casein kinase 2 (CK2) with activity at both the CK2A2 and CK2A1 isoforms (IC₅₀ values are 2.3-16 nM and 4.2-36 nM respectively). SGC CK-1 also inhibits DYRK2 (IC₅₀ = 440 nM).

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CK2-1 probe summary on the SGC website.

External Portal Information for SGC CK2-1

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC CK2-1 is reviewed on the chemical probes website.

化合物库 for SGC CK2-1

SGC CK2-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SGC CK2-1

分子量	375.44
公式	C₂₀H₂₁N₇O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2470424-39-4
PubChem ID	146681133
InChI Key	YKDZIFFKQUNVHH-UHFFFAOYSA-N
Smiles	CCC(NC1=C(C=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=C1)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SGC CK2-1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	37.54	100

制备储备液 for SGC CK2-1

以下数据基于产品分子量 375.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.32 mL	26.64 mL
5 mM	0.53 mL	2.66 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for SGC CK2-1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SGC CK2-1

参考文献是支持产品生物活性的出版物。

Wells et al (2021) Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem.Biol. 28 546 PMID: 33484635

If you know of a relevant reference for SGC CK2-1, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Casein Kinase 2 Inhibitors

关键词: SGC CK2-1, SGC CK2-1 supplier, SGCCK2-1, SGCCK21, casein, kinases, inhibitors, CK2, CK2A2, CK2A1, DYRK2, potent, SGC, Casein, Kinase, 2, DYRK, 7450, Tocris Bioscience

1 篇 SGC CK2-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SGC CK2-1 的部分引用包括：

Carmine et al (2022) Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Sci Adv 8 eabo1215 PMID: 36044577

您是否知道使用了 Tocris SGC CK2-1 的优秀论文？请告知我们.

SGC CK2-1 的评论

目前没有该产品的评论。 Be the first to review SGC CK2-1 and earn rewards!

Have you used SGC CK2-1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

Cell Cycle and Mitosis
DNA Damage Repair
Targeted Protein Degradation
Ubiquitin Proteasome Pathway
Chemotherapy Targets