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SGC GAK 1

Cat. No. 6564 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity cyclin G associated kinase (GAK) inhibitor
化学名： 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SGC GAK 1

SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor (Kd = 1.9 nM). Exhibits >30-fold selectivity for GAK over a panel of other kinases. Inhibits GAK in live cell assays (IC50 = 110 nM).

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC GAK 1 probe summary on the SGC website.

化合物库 for SGC GAK 1

SGC GAK 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SGC GAK 1

分子量 389.24
公式 C18H17BrN2O3
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 2226517-76-4
PubChem ID 50877865
InChI Key JVUVMZJTEXYQNS-UHFFFAOYSA-N
Smiles BrC1=CC2=C(NC3=CC(OC)=C(OC)C(OC)=C3)C=CN=C2C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SGC GAK 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.92 100
ethanol 19.46 50

制备储备液 for SGC GAK 1

以下数据基于产品分子量 389.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.85 mL 25.69 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for SGC GAK 1

参考文献是支持产品生物活性的出版物。

Asquith et al (2019) SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK). J.Med.Chem. 62 2830 PMID: 30768268

Asquith et al (2019) Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg.Med.Chem.Lett. 29 1727 PMID: 31129055

If you know of a relevant reference for SGC GAK 1, please let us know.

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关键词: SGC GAK 1, SGC GAK 1 supplier, SGCGAK1, cyclin, G, associated, kinases, inhibitors, inhibits, serine/threonine, GAK, Other, Kinases, 6564, Tocris Bioscience

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