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说明： MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
化学名： N1-((1H-Indol-5-yl)methyl)-N3-(quinolin-4-yl)propane-1,3-diamine
纯度： ≥98% (HPLC)
生物活性 for SJ 1008066
SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC50 = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.
许可信息
Sold under license from St. Jude Children's Research Hospital.
化合物库 for SJ 1008066
SJ 1008066 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SJ 1008066
| 分子量 | 330.44 |
| 公式 | C21H22N4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2758867-71-7 |
| PubChem ID | 162444676 |
| InChI Key | UMJWTJVGTTUEQK-UHFFFAOYSA-N |
| Smiles | C12=C(C=CC=C2)C(NCCCNCC3=CC4=C(C=C3)NC=C4)=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SJ 1008066
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.04 | 100 |
制备储备液 for SJ 1008066
以下数据基于产品分子量 330.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.13 mL | 30.26 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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产品说明书 for SJ 1008066
参考文献 for SJ 1008066
参考文献是支持产品生物活性的出版物。
Yang et al (2020) Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat.Commun. 11 4931 PMID: 33004795
If you know of a relevant reference for SJ 1008066, please let us know.
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关键词: SJ 1008066, SJ 1008066 supplier, SJ1008066, cell, permeable, inhibitors, inhibits, testis-restricted, melanoma, antigen, protein, MAGE-A11, disrupts, MAGE-A11:PCF11, interaction, Ubiquitin, E3, Ligases, 7542, Tocris Bioscience
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