SLM 6031434 hydrochloride

Cat. No. 6281 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective sphingosine kinase 2 (Sphk2) inhibitor

化学名： (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is a Sphk2 inhibitor (K_i = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

许可信息

Sold with the permission of the University of Virginia Patent Foundation

化合物库 for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SLM 6031434 hydrochloride

分子量	489.96
公式	C₂₂H₃₀F₃N₅O₂.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1897379-34-8
PubChem ID	134812833
InChI Key	YIGAQKBPLMSWOD-LMOVPXPDSA-N
Smiles	CCCCCCCCOC1=C(C(F)(F)F)C=C(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SLM 6031434 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	9.8	20
	DMSO	49	100

制备储备液 for SLM 6031434 hydrochloride

以下数据基于产品分子量 489.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.2 mL	20.41 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.2 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

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产品说明书 for SLM 6031434 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SLM 6031434 hydrochloride

参考文献是支持产品生物活性的出版物。

Kharel et al (2015) Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 355 23 PMID: 26243740

Schwalm et al (2021) Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 79 PMID: 33301900

If you know of a relevant reference for SLM 6031434 hydrochloride, please let us know.

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