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SP 141

Cat. No. 5332 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity MDM2 inhibitor
化学名： 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SP 141

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

化合物库 for SP 141

SP 141 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SP 141

分子量 324.38
公式 C22H16N2O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1253491-42-7
PubChem ID 59620153
InChI Key AABFWJDLCCDJJN-UHFFFAOYSA-N
Smiles COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SP 141

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.44 100
ethanol 32.44 100

制备储备液 for SP 141

以下数据基于产品分子量 324.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for SP 141

参考文献是支持产品生物活性的出版物。

Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086 PMID: 25271708

If you know of a relevant reference for SP 141, please let us know.

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关键词: SP 141, SP 141 supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Ubiquitin, E3, Ligases, p53, 5332, Tocris Bioscience

2 篇 SP 141 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SP 141 的部分引用包括：

Weiming et al (2023) MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma. Pathol Oncol Res 29 1610801 PMID: 36741966

Carol et al (2021) MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proc Natl Acad Sci U S A 118 PMID: 34716260

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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