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Takinib

Cat. No. 6430 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective TAK1/MAP3K7 kinase inhibitor
化学名： N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Takinib

Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC50 = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC50 values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.

化合物库 for Takinib

Takinib is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Takinib

分子量 322.37
公式 C18H18N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1111556-37-6
PubChem ID 37750349
InChI Key UOZVVPXKJGOFIG-UHFFFAOYSA-N
Smiles CCCN1C(NC(C2=CC(C(N)=O)=CC=C2)=O)=NC3=CC=CC=C13

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Takinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.24 100

制备储备液 for Takinib

以下数据基于产品分子量 322.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.51 mL 31.02 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for Takinib

参考文献是支持产品生物活性的出版物。

Totzke et al (2017) Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-α inhibition for cancer and autoimmune disease. Cell Chem.Biol. 24 1029 PMID: 28820959

If you know of a relevant reference for Takinib, please let us know.

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关键词: Takinib, Takinib supplier, Potent, selective, TAK1, MAP3K7, kinase, inhibitors, inhibits, rheumatoid, arthritis, TGFbeta, TGFβ, activated, kinases, TGFb, Other, Kinases, 6430, Tocris Bioscience

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