TBB

Cat. No. 2275 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective cell-permeable CK2 inhibitor

别名： NSC 231634

化学名： 4,5,6,7-Tetrabromobenzotriazole

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TBB

TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC₅₀ = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K_i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

化合物库 for TBB

TBB is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TBB

分子量	434.71
公式	C₆HBr₄N₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	17374-26-4
PubChem ID	1694
InChI Key	OMZYUVOATZSGJY-UHFFFAOYSA-N
Smiles	BrC1=C2NN=NC2=C(Br)C(Br)=C1Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TBB

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	43.47	100

制备储备液 for TBB

以下数据基于产品分子量 434.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.3 mL	11.5 mL	23 mL
5 mM	0.46 mL	2.3 mL	4.6 mL
10 mM	0.23 mL	1.15 mL	2.3 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for TBB

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TBB

参考文献是支持产品生物活性的出版物。

Sarno et al (2001) Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 496 44 PMID: 11343704

Pagano et al (2004) Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J.Med.Chem. 47 6239 PMID: 15566294

Zien et al (2005) Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 1754 271 PMID: 16203192

If you know of a relevant reference for TBB, please let us know.

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关键词: TBB, TBB supplier, Selective, cell-permeable, CK2, inhibitors, inhibits, Casein, Kinase, 2, Kinases, NSC231634, NSC, 231634, 2275, Tocris Bioscience