TC ASK 10

Cat. No. 4825 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective ASK1 inhibitor; orally bioavailable

化学名： 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC ASK 10

TC ASK 10 is a potent ASK1 inhibitor (IC₅₀ = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC₅₀ = 0.51 μM), MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf (IC₅₀ values are > 10 μM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable.

化合物库 for TC ASK 10

TC ASK 10 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC ASK 10

分子量	432.35
公式	C₂₁H₂₁N₅O.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1005775-56-3
PubChem ID	68661090
InChI Key	IKKLFEDUYFZNBO-UHFFFAOYSA-N
Smiles	O=C(C4=CC=C(C(C)(C)C)C=C4)NC1=CN2C(C=CC(N3C=NC=C3)=C2)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC ASK 10

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	43.23	100
	DMSO	43.23	100

制备储备液 for TC ASK 10

以下数据基于产品分子量 432.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.56 mL	23.13 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for TC ASK 10

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC ASK 10

参考文献是支持产品生物活性的出版物。

Terao et al (2012) Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg.Med.Chem.Lett. 22 7326 PMID: 23147077

If you know of a relevant reference for TC ASK 10, please let us know.

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关键词: TC ASK 10, TC ASK 10 supplier, TCASK10, apoptosis, signal, regulating, kinase, ASK1, potent, selective, inhibitors, inhibits, cell, permeable, active, orally, bioavailable, Other, ER, stress/UPR, 4825, Tocris Bioscience

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