TC-S 7006

Cat. No. 5240 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

化学名： 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

纯度： ≥99% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC-S 7006

TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC₅₀ = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8⁺ cytotoxic T lymphocytes. Cell permeable.

化合物库 for TC-S 7006

TC-S 7006 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-S 7006

分子量	404.83
公式	C₂₁H₁₄ClFN₆
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	871307-18-5
PubChem ID	9549300
InChI Key	NMEUKWOOQOHUNA-UHFFFAOYSA-N
Smiles	FC(C(Cl)=C4)=CC=C4NC1=C2C(C=NC(NCC3=CN=CC=C3)=C2)=NC=C1C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-S 7006

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.48	100

制备储备液 for TC-S 7006

以下数据基于产品分子量 404.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.35 mL	24.7 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for TC-S 7006

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-S 7006

参考文献是支持产品生物活性的出版物。

Chowdhury et al (2014) Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions. PLoS ONE 9 e92187 PMID: 24642963

Wang et al (2010) Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27^Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D₃. Cell Cycle 9 4542 PMID: 21084834

Gavrin et al (2005) Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg.Med.Chem.Lett. 15 5288 PMID: 16165349

If you know of a relevant reference for TC-S 7006, please let us know.

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关键词: TC-S 7006, TC-S 7006 supplier, TC-S7006, potent, selective, TPL2, Cot, MAP3K8, inhibits, inhibitors, Other, Kinases, 5240, Tocris Bioscience

1 篇 TC-S 7006 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-S 7006 的部分引用包括：

Matzaraki et al (2017) An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS One 12 e0180824 PMID: 28727728

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