主页 / 药理学 / Enzymes / Kinases / PI 3-kinase / PI 3-kinase Inhibitors / TGX 221

TGX 221

Cat. No. 5832 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective PI 3-kinase β inhibitor
化学名： 7-Methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TGX 221

TGX 221 is a potent and selective PI 3-kinase β inhibitor (IC50 values are 0.007, 0.1, 3.5 and 5 μM for the β, δ, γ and α isoforms, respectively). Shows >1,000-fold selectively for PI 3-kinase β over a range of other kinases. Inhibits thrombus formation in animal models.

化合物库 for TGX 221

TGX 221 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TGX 221

分子量 364.44
公式 C21H24N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 663619-89-4
PubChem ID 9907093
InChI Key CPRAGQJXBLMUEL-UHFFFAOYSA-N
Smiles CC(C1=CC(C)=CN2C(C=C(N3CCOCC3)N=C12)=O)NC4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TGX 221

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.22 50

制备储备液 for TGX 221

以下数据基于产品分子量 364.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.49 mL 27.44 mL 54.88 mL
2.5 mM 1.1 mL 5.49 mL 10.98 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
25 mM 0.11 mL 0.55 mL 1.1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for TGX 221

参考文献是支持产品生物活性的出版物。

Condliffe et al (2005) Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 1432 PMID: 15878979

Jackson et al (2005) PI 3-kinase p110β: a new target for antithrombotic therapy. Nat.Med. 11 507 PMID: 15834429

If you know of a relevant reference for TGX 221, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PI 3-kinase Inhibitors

关键词: TGX 221, TGX 221 supplier, TGX221, PI3K, PI, 3-kinase, phosphoinositide, potent, selective, inhibits, inhibitors, beta, β, antithrombotic, 3-Kinase, 5832, Tocris Bioscience

篇 TGX 221 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 TGX 221 的引用文献。 您是否知道使用了 Tocris TGX 221 的优秀论文？ 请告知我们.

TGX 221 的评论

目前没有该产品的评论。 Be the first to review TGX 221 and earn rewards!

Have you used TGX 221?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review