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说明： Inhibitor of IP6K; also inhibits IP3K
化学名： N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
纯度： ≥97% (HPLC)
生物活性 for TNP
TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).
技术数据 for TNP
| 分子量 | 443.38 |
| 公式 | C20H16F3N7O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 519178-28-0 |
| PubChem ID | 16760513 |
| InChI Key | DDSBPUYZPWNNGH-UHFFFAOYSA-N |
| Smiles | O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TNP
参考文献 for TNP
参考文献是支持产品生物活性的出版物。
Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622
Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991
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关键词: TNP, TNP supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, 3946, Tocris Bioscience
1 篇 TNP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TNP 的部分引用包括：
Andrew M et al (2022) Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals. Acta Physiol (Oxf) 235 e13815 PMID: 35334154
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