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TNP

Cat. No. 3946 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of IP6K; also inhibits IP3K
化学名： N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TNP

TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).

技术数据 for TNP

分子量 443.38
公式 C20H16F3N7O2
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 519178-28-0
PubChem ID 16760513
InChI Key DDSBPUYZPWNNGH-UHFFFAOYSA-N
Smiles O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TNP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.34 100
ethanol 11.08 25

制备储备液 for TNP

以下数据基于产品分子量 443.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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产品说明书 for TNP

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TNP

参考文献是支持产品生物活性的出版物。

Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622

Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991

If you know of a relevant reference for TNP, please let us know.

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关键词: TNP, TNP supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, 3946, Tocris Bioscience

1 篇 TNP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TNP 的部分引用包括：

Andrew M et al (2022) Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals. Acta Physiol (Oxf) 235 e13815 PMID: 35334154

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