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TTP 22

Cat. No. 4432 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity, selective CK2 inhibitor
化学名： 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TTP 22

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μM).

化合物库 for TTP 22

TTP 22 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TTP 22

分子量 330.42
公式 C16H14N2O2S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 329907-28-0
PubChem ID 1536915
InChI Key RAOULLCLLOGTDA-UHFFFAOYSA-N
Smiles CC(C=C3)=CC=C3C1=CSC2=C1C(SCCC(O)=O)=NC=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TTP 22

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.04 100
ethanol 6.61 20

制备储备液 for TTP 22

以下数据基于产品分子量 330.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for TTP 22

参考文献是支持产品生物活性的出版物。

Golub et al (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur.J.Med.Chem. 46 870 PMID: 21276643

If you know of a relevant reference for TTP 22, please let us know.

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关键词: TTP 22, TTP 22 supplier, casein, kinase, 2, CK2, inhibits, inhibitors, selective, high, affinity, ATP, competitive, TTP22, Casein, Kinase, 4432, Tocris Bioscience

2 篇 TTP 22 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TTP 22 的部分引用包括：

Till S et al (2021) The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis. Commun Biol 4 336 PMID: 33712726

Didier Y R et al (2021) Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures. Elife 10 PMID: 34586063

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