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UNC 3230

Cat. No. 5271 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PIP5K1C inhibitor; antinociceptive
化学名： 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for UNC 3230

UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

化合物库 for UNC 3230

UNC 3230 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for UNC 3230

分子量 344.43
公式 C17H20N4O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1031602-63-7
PubChem ID 46355372
InChI Key RZCNASHHHSKTGP-UHFFFAOYSA-N
Smiles O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UNC 3230

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.44 100

制备储备液 for UNC 3230

以下数据基于产品分子量 344.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.52 mL 29.03 mL
5 mM 0.58 mL 2.9 mL 5.81 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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参考文献 for UNC 3230

参考文献是支持产品生物活性的出版物。

Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836 PMID: 24853942

If you know of a relevant reference for UNC 3230, please let us know.

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关键词: UNC 3230, UNC 3230 supplier, UNC3230, potent, selective, PIP5K1C, inhibitors, inhibits, antinociceptive, reduces, nociception, chronic, pain, phosphatidylinositol-4-phosphate, 5-kinase, type, I, gamma, Other, Kinases, 5271, Tocris Bioscience

3 篇 UNC 3230 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UNC 3230 的部分引用包括：

Peng et al (2019) Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine PMID: 31105034

Ying et al (2017) INPP5E Preserves Genomic Stability through Regulation of Mitosis. Mol Cell Biol 37 PMID: 28031327

Christopher J et al (2021) Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PLoS Genet 17 e1009354 PMID: 33591981

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