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WHI-P 154

Cat. No. 3115 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3115 has been discontinued.

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说明： JAK3 kinase inhibitor. Also inhibits EGFR
化学名： 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
纯度： ≥99% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for WHI-P 154

WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Induces differentiation of neural progenitor cells.

技术数据 for WHI-P 154

分子量 376.2
公式 C16H14BrN3O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 211555-04-3
PubChem ID 3795
InChI Key CBIAKDAYHRWZCU-UHFFFAOYSA-N
Smiles OC(C=C3)=C(Br)C=C3NC2=NC=NC1=CC(OC)=C(OC)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for WHI-P 154

参考文献是支持产品生物活性的出版物。

Narla et al (1998) 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. Clin.Cancer Res. 4 1405 PMID: 9626456

Sareila et al (2008) Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-α. Int.Immunopharmacol. 8 100 PMID: 18068105

Changelian et al (2008) The specificity of JAK3 kinase inhibitors. Blood 111 2155 PMID: 18094329

Kim et al (2010) Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway. Stem Cells. 28 1816 PMID: 20979137

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关键词: WHI-P 154, WHI-P 154 supplier, JAK3, kinases, inhibitors, inhibits, EGFR, Potent, Janus, Activated, Kinases, Epidermal, Growth, Factor, Receptors, ErbB, Her, Receptor, Tyrosine, RTKs, WHIP154, JAK, Kinase, Neural, Stem, Cells, 3115, Tocris Bioscience

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Pathways for WHI-P 154

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.