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ZM 449829

Cat. No. 1366 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1366 has been discontinued.

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说明： Potent, selective JAK3 inhibitor
化学名： 1-(2-Naphthalenyl)-2-propen-1-one
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for ZM 449829

ZM 449829 is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.

许可信息

Sold with the permission of AstraZeneca Ltd.

技术数据 for ZM 449829

分子量 182.22
公式 C13H10O
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 4452-06-6
PubChem ID 3799
InChI Key FOTCGZPFSUWZBN-UHFFFAOYSA-N
Smiles C=CC(C2=CC1=CC=CC=C1C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ZM 449829

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ZM 449829

参考文献是支持产品生物活性的出版物。

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557

Orange et al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535 PMID: 21383498

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关键词: ZM 449829, ZM 449829 supplier, Potent, selective, JAK3, inhibitors, inhibits, JAK, Kinase, Janus, Activated, Kinases, ZM449829, AstraZeneca, 1366, Tocris Bioscience

4 篇 ZM 449829 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZM 449829 的部分引用包括：

Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409

Gross et al (2006) The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291 H827 PMID: 16517948

Lu et al (2008) JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem 21 305 PMID: 18441519

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. PLoS One 10 e0143319 PMID: 26619345

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Pathways for ZM 449829

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.