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1,2,3,4,5,6-Hexabromocyclohexane

Cat. No. 2291 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

2291 has been discontinued.

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Description: Inhibits JAK2 autophosphorylation
Alternative Names: NSC 7908
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for 1,2,3,4,5,6-Hexabromocyclohexane

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Technical Data for 1,2,3,4,5,6-Hexabromocyclohexane

M. Wt 557.54
Formula C6H6Br6
Storage Store at RT
CAS Number 1837-91-8
PubChem ID 74603
InChI Key QFQZKISCBJKVHI-UHFFFAOYSA-N
Smiles BrC1C(C(C(C(C1Br)Br)Br)Br)Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 1,2,3,4,5,6-Hexabromocyclohexane

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for 1,2,3,4,5,6-Hexabromocyclohexane

References are publications that support the biological activity of the product.

Sandberg et al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526 PMID: 15801842

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Keywords: 1,2,3,4,5,6-Hexabromocyclohexane, 1,2,3,4,5,6-Hexabromocyclohexane supplier, inhibitors, inhibits, JAK2, autophosphorylation, Kinases, Janus, Activated, NSC7908, NSC, 7908, JAK, Kinase, 2291, Tocris Bioscience

1 Citation for 1,2,3,4,5,6-Hexabromocyclohexane

Citations are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Genes Dev 10 e0143319 PMID: 26619345

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Pathways for 1,2,3,4,5,6-Hexabromocyclohexane

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.