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Atiprimod dihydrochloride

Cat. No. 4580 Submit a Review Datasheet / COA / SDS

Discontinued Product

4580 has been discontinued.

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Description: JAK2 inhibitor
Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride
Datasheet
Citations
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Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Atiprimod dihydrochloride

Atiprimod dihydrochloride is a JAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.

Technical Data for Atiprimod dihydrochloride

M. Wt 409.52
Formula C22H44N2.2HCl
Storage Desiccate at RT
CAS Number 130065-61-1
PubChem ID 166556
InChI Key MOUZYBYTICOTFQ-UHFFFAOYSA-N
Smiles CCCC1(CCC)CCC2(CN(CCCN(CC)CC)CC2)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Atiprimod dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Atiprimod dihydrochloride

References are publications that support the biological activity of the product.

Manshouri et al (2011) Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71 3831 PMID: 21512135

Quintás-Cardama et al (2011) Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest.New Drugs 29 818 PMID: 20372971

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Keywords: Atiprimod dihydrochloride, Atiprimod dihydrochloride supplier, JAK2, kinases, inhibitors, inhibits, induces, apoptosis, proapoptotic, janus, activated, STAT3, STAT5, JAK, Kinase, 4580, Tocris Bioscience

Citations for Atiprimod dihydrochloride

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Pathways for Atiprimod dihydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.