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Submit ReviewHerbimycin A
Description: Src family kinase inhibitor. Also Hsp90 inhibitor
Chemical Name: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
Purity: ≥95% (HPLC)
Biological Activity for Herbimycin A
Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.
Technical Data for Herbimycin A
| M. Wt | 574.67 |
| Formula | C30H42N2O9 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 70563-58-5 |
| PubChem ID | 6436247 |
| InChI Key | MCAHMSDENAOJFZ-GDYSMBPZSA-N |
| Smiles | O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Herbimycin A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1 | 2 |
Preparing Stock Solutions for Herbimycin A
The following data is based on the product molecular weight 574.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 87.01 mL | 435.03 mL | 870.06 mL |
| 0.1 mM | 17.4 mL | 87.01 mL | 174.01 mL |
| 0.2 mM | 8.7 mL | 43.5 mL | 87.01 mL |
| 1 mM | 1.74 mL | 8.7 mL | 17.4 mL |
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Product Datasheets for Herbimycin A
References for Herbimycin A
References are publications that support the biological activity of the product.
Fukazawa et al (1994) Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett. 340 155 PMID: 8131836
McCollum et al (2004) Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp.Eye Res. 78 987 PMID: 15051479
Duncan (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 272 5244 PMID: 16218955
If you know of a relevant reference for Herbimycin A, please let us know.
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Keywords: Herbimycin A, Herbimycin A supplier, Hsp90, inhibitors, inhibits, Src, family, kinase, Heat, Shock, Protein, 90, p60v-src, p210BCR-ABL, Kinases, HerbimycinA, antibiotics, Antiangiogenics, Antibiotics, 1629, Tocris Bioscience
Citations for Herbimycin A
Citations are publications that use Tocris products.
Currently there are no citations for Herbimycin A. Do you know of a great paper that uses Herbimycin A from Tocris? Please let us know.
Reviews for Herbimycin A
Average Rating: 5 (Based on 1 Review.)
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We studied mechanisms of resistance to Herbimycin A.
By
Anonymous on 02/27/2019
Species: Human
We studied mechanisms of resistance to Herbimycin A (ansamycin antibiotics) in human breast cancer cell lines.
