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L-Azidonorleucine hydrochloride

Cat. No. 6585 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
Chemical Name: (S)-2-Amino-6-azidohexanoic acid hydrochloride
Datasheet
Citations
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Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for L-Azidonorleucine hydrochloride

L-Azidonorleucine hydrochloride is an unnatural amino acid; methionine surrogate. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.

Technical Data for L-Azidonorleucine hydrochloride

M. Wt 208.65
Formula C6H12N4O2.HCl
Storage Store at -20°C
CAS Number 1454334-76-9
PubChem ID 121235322
InChI Key RCEAACZNVVRXSJ-JEDNCBNOSA-N
Smiles N[C@H](C(O)=O)CCCCN=[N+]=[N-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-Azidonorleucine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.86 100

Preparing Stock Solutions for L-Azidonorleucine hydrochloride

The following data is based on the product molecular weight 208.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.79 mL 23.96 mL 47.93 mL
5 mM 0.96 mL 4.79 mL 9.59 mL
10 mM 0.48 mL 2.4 mL 4.79 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets for L-Azidonorleucine hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for L-Azidonorleucine hydrochloride

References are publications that support the biological activity of the product.

Alvarez-Castelao et al (2017) Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nat.Biotechnol. 35 1196 PMID: 29106408

Mahdavi et al (2016) Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis. J.Am.Chem.Soc. 138 4278 PMID: 26991063

If you know of a relevant reference for L-Azidonorleucine hydrochloride, please let us know.

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Citations for L-Azidonorleucine hydrochloride

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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