Home / Product Type / Reagents / Biochemicals and Molecular Biology / LaKe

LaKe

Cat. No. 8888 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Orally bioavailable prodrug metabolite, undergoes hydrolytic conversion to yield (S)-lactate and (R)-1,3-butanediol in cells
Chemical Name: (3R)-3-Hydroxybutyl (2S)-2-hydroxypropanoate and (1R)-3-Hydroxy-1-methylpropyl (2S)-2-hydroxypropanoate
Purity: ≥95%
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for LaKe

LaKe is a metabolite that undergoes hydrolytic conversion to yield (S)-lactate (Lac) and (R)-1,3-butanediol (BHB) in cells, two metabolites naturally released during strenuous exercise and prolonged fasting. In vivo, oral ingestion of LaKe in rats, results in an increase of Lac and BHB plasma levels, triggering reduced lipolysis and elevation of the appetite-suppressing compound Lac-Phe (Cat. No. 7942).

Licensing Information

Sold under license from Mmimetika Biosciences

Technical Data for LaKe

M. Wt 162.19
Formula C7H14O4
Storage Store at -20°C
Purity ≥95%
InChI Key YYIHZASOYSUEJO-NTPRZCPUSA-N
Smiles C[C@@H](C(O[C@@H](CCO)C)=O)O.C[C@@H](C(OCC[C@@H](C)O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LaKe

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.22 100

Preparing Stock Solutions for LaKe

The following data is based on the product molecular weight 162.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.17 mL 30.83 mL 61.66 mL
5 mM 1.23 mL 6.17 mL 12.33 mL
10 mM 0.62 mL 3.08 mL 6.17 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for LaKe

References are publications that support the biological activity of the product.

Ottosen et al (2024) Preparation and preclinical characterization of a simple ester for dual exogenous supply of lactate and beta-hydroxybutyrate. J.Agric.Food Chem. 72 19883 PMID: 39214666

If you know of a relevant reference for LaKe, please let us know.

View Related Products by Target

Keywords: LaKe, LaKe supplier, lactate, ketones, N-L-lactoyl-phenylalanine, Lac-Phe, appetite, regulation, orally, bioavailable, in, vivo, exercise, Biochemicals, and, Molecular, Biology, 8888, Tocris Bioscience

Citations for LaKe

Citations are publications that use Tocris products.

Currently there are no citations for LaKe. Do you know of a great paper that uses LaKe from Tocris? Please let us know.

Reviews for LaKe

There are currently no reviews for this product. Be the first to review LaKe and earn rewards!

Have you used LaKe?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review