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Description: DNA ligase I, III and IV inhibitor
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Biological Activity for L189
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
Technical Data for L189
| M. Wt | 246.29 |
| Formula | C11H10N4OS |
| Storage | Store at -20°C |
| CAS Number | 64232-83-3 |
| PubChem ID | 824710 |
| InChI Key | SAKOXVNKDMWWLF-UHFFFAOYSA-N |
| Smiles | S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L189
References for L189
References are publications that support the biological activity of the product.
Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169 PMID: 18451142
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Keywords: L189, L189 supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Ligases, 3561, Tocris Bioscience
1 Citation for L189
Citations are publications that use Tocris products. Selected citations for L189 include:
Kempegowda et al (2018) Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner. FEBS J 285 3959-3976 PMID: 30230716
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