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Submit ReviewLY 303511
Description: Negative control of LY 294002 (Cat. No. 1130)
Chemical Name: 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one
Purity: ≥99% (HPLC)
Biological Activity for LY 303511
LY 303511 is a negative control compound for LY 294002 PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Also inhibits the BET bromodomain proteins BRD2, BRD3 and BRD4.
Active Analog also available.
Technical Data for LY 303511
| M. Wt | 306.36 |
| Formula | C19H18N2O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 154447-38-8 |
| PubChem ID | 3971 |
| InChI Key | NGAGMBNBKCDCDJ-UHFFFAOYSA-N |
| Smiles | O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 303511
References for LY 303511
References are publications that support the biological activity of the product.
El-kholy et al (2003) The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks KV currents via a direct mechanism. FASEB J. 17 720 PMID: 12586735
Choi et al (2004) LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. FEBS Letters. 559 141 PMID: 14960322
Kristof et al (2005) LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J.Pharmacol.Exp.Ther. 314 1134 PMID: 15923340
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Keywords: LY 303511, LY 303511 supplier, Negative, control, LY, 294002, LY294002, PI3K, Phosphoinositide, PI, 3-Kinases, PIP2, Inositol, Lipids, LY303511, BETbromodomains, inhibitors, inhibits, BRD2, BRD3, BRD4, 3-Kinase, Bromodomains, 2418, Tocris Bioscience
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